NCT01730352

Helicobacter Pylori Treatment in Immune Thrombocytopenic Purpura (ITP) Patients

Helicobacter Pylori Infection and Chronic Immune Thrombocytopenic Purpura in Children and Adolescents - A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Federal University of São Paulo · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether eradication of Helicobacter pylori infection is effective in the improvement of platelet counts in children and adolescents with chronic ITP.

Detailed description

Helicobacter pylori infection has been associated with Immune Thrombocytopenic Purpura (ITP), and there is scientific evidence for the investigation and treatment of this bacterium for adult patients with ITP. However, in children this causal association is not clear, with few published studies.

Conditions

• Immune Thrombocytopenic Purpura
• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	H. pylori triple therapy	Children up to 5 years: clarithromycin 15mg/kg, amoxicillin 50mg/kg, and/or furazolidone 7mg/kg Children above 8 years: doxycycline 4,4mg/kg if necessary Children able to swallow tablets or capsules, above 30kg: clarithromycin 500mg, amoxicillin 500mg, furazolidone 200mg, and/ or doxycycline 100mg, all 2 times per day, for 14 days.

Timeline

• Start date: 2008-10-01
• Primary completion: 2011-05-01
• Completion: 2012-03-01
• First posted: 2012-11-21
• Last updated: 2012-11-21

Locations

4 sites across 1 country: Brazil