NCT01727427

Prospective Study on the Treatment of Unsuspected Pulmonary Embolism in Cancer Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 695 (actual)
• Sponsor: G. d'Annunzio University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The same initial and long-term anticoagulation is suggested for unsuspected pulmonary embolism as for patients with symptomatic embolism. Based on these indications, cancer patients with unsuspected pulmonary embolism would be anticoagulated for at least 6 months or until the disease is active, which in most cases would mean indefinite treatment. In fact, dedicated studies on the treatment of unsuspected pulmonary embolism are missing, leaving doubts over the need for (indefinite) anticoagulation which exposes these patients to an increased risk of major bleeding events. Concerns over the need for anticoagulant treatment may especially hold for pulmonary embolism of the distal pulmonary tree since segmental and sub-segmental PE seem to have a more benign course than more proximal embolism. The scope of this study is to evaluate the current treatment approaches for unsuspected pulmonary embolism and to assess their efficacy and safety in a large prospective cohort of cancer patients.

Conditions

• Unsuspected Pulmonary Embolism

Interventions

Type	Name	Description
DRUG	Heparin, fondaparinux, vitamin-K antagonists, aspirin	Parenteral or oral anticoagulant Antiplatelet agent

Timeline

• Start date: 2012-11-01
• Primary completion: 2017-12-01
• Completion: 2017-12-01
• First posted: 2012-11-16
• Last updated: 2019-08-08

Locations

46 sites across 8 countries: United States, Austria, Canada, France, Germany, Italy, Netherlands, Spain