NCT01726322

Ovarian Reserve in Premenopausal Breast Cancer

A Study to Determine Alteration of Hormone Levels in Premenopausal Patients Receiving Adjuvant or Neo-adjuvant Chemotherapy for Breast Cancer

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 216 (actual)
• Sponsor: Cancer Trials Ireland · Network
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This is a translational, mutlicentre study. The aim of this study is to determine whether pre-treatment levels of hormones predict ovarian follicular reserve post adjuvant or neoadjuvant chemotherapy for breast cancer and chemotherapy induced amenorrhea.

Detailed description

It is proposed that levels of AMH and inhibin A and B measured will give an indication of the residual ovarian reserve in women with breast cancer treated with chemotherapy. In addition, AMH might give an indication of the possible efficacy of GNRH agonists in fertility preservation and the effect on ovarian follicular reserve using different adjuvant chemotherapy regimens. Those likely to be offered GNRH agonists are younger women with no children and a wish to have some in the future. Older women who have completed their families are less likely to be offered a GNRH agonist.

Conditions

• Premenopausal Breast Cancer
• Breast Cancer

Timeline

• Start date: 2012-09-01
• Primary completion: 2020-07-13
• Completion: 2020-07-13
• First posted: 2012-11-14
• Last updated: 2025-07-08

Locations

10 sites across 1 country: Ireland