NCT01723111

Impact of Dialysis Modality on Hepcidin and Iron Metabolism

A Prospective, Multicenter, Observational Study to Evaluate the Impact of Peritoneal Dialysis Compared With Hemodialysis on Iron Metabolism and Hepcidin

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Kyungpook National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

* Dialysis modality may influence the oxidative stress and proinflammatory cytokines in ESRD patients. * Dialysis modality may affect hepcidin * Dialysis modality may influence iron and ESA requirements.

Detailed description

It has been considered that PD patients tended to be less anemic and require lower ESA dose than HD patients. In addition, it was also known that the level of oxidative stress and inflammatory cytokines tended to be lower in PD patients than HD patients. And hepcidin synthesis is markedly increased during inflammation. Altogether, Lower ESA requirement in PD patients may be associated with lower hepcidin level due to lower inflammatory state compared with HD patients.

Conditions

• End-stage Renal Disease

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-02-01
• Completion: 2016-08-01
• First posted: 2012-11-07
• Last updated: 2017-08-22

Locations

4 sites across 1 country: South Korea