NCT01722396

Pharmacogenetics of Vitamin D Supplementation in Tuberculosis

The Pharmacogenetics of Vitamin D Supplementation in Tuberculosis

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: University of Birmingham · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

Previous studies of vitamin D supplementation have suggested there may be differences in response between individuals. This study is an open label study of vitamin D supplementation in patients with active or latent tuberculosis in which active disease patients take 100000units of vitamin D every 8 weeks during their tuberculosis treatment. Genotyping for relevant vitamin D pathway polymorphisms will be carried out and related to clinical and ex vivo markers of vitamin D response. Latent patients will only be studied for vitamin D response ex vivo. Our hypothesis is that response to vitamin D in both monocytes and T cells will be related to polymorphisms in the DBP gene, and that this may relate to clinical response in terms of post supplementation vitamin D level.

Conditions

• Tuberculosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D

Timeline

• Start date: 2011-03-01
• Primary completion: 2012-11-01
• Completion: 2012-11-01
• First posted: 2012-11-06
• Last updated: 2013-01-16

Locations

1 site across 1 country: United Kingdom