NCT01719419

The Effect of Modified Sham Feeding With Orlistat in Overweight and Obese Subjects

The Effect of Modified Sham Feeding With Orlistat in Overweight and Obese Subjects: A Pilot Study

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if the drug orlistat (Alli, Xenical) decreases the taste for fat in humans.

Detailed description

One screening visit and Testing Visits 1 and 2: Approximately 1-2 hours (Fasting - You will have nothing to eat or drink (except water or medications) after midnight before the test visit.) If you qualify for the study, you will return to Pennington Biomedical Research Center for the test visit * You will be given a questionnaire to screen for allergies or cold symptoms. * Women will answer a questionnaire based on their menstrual cycle. * Before eating, you will be given instructions on how to use the study medication. You will swish about 2 teaspoons of a solution in your mouth for 30 seconds and then spit it out (like mouthwash). * Just before eating, you will be given another brief questionnaire judging your appetite. * You will be given the test meal. You will be allowed to eat as much or as little as you like during a 20-minute eating period. * 30 minutes after starting your meal you will be given the brief questionnaire again to judge your appetite. * You will return in 1 month to complete test visit 2.

Conditions

• Overweight

Interventions

Type	Name	Description
DRUG	Placebo	Measured fatty food intake and appetite at a single lunch meal after the administration of modified sham feeding technique with placebo.
DRUG	Orlistat	Measured fatty food intake and appetite at a single lunch meal after the administration of modified sham feeding technique with orlistat.

Timeline

• Start date: 2012-03-01
• Primary completion: 2012-09-01
• Completion: 2012-09-01
• First posted: 2012-11-01
• Last updated: 2015-12-18

Locations

1 site across 1 country: United States