NCT01716819

Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity

Role of the Renin Angiotensin Aldosterone System and Remodeling of the Matrix Cardiac Extra Cellular in the Mechanisms of Transition to Heart Failure in Abdominal Obesity: Prospective Longitudinal Study R2C2 II

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 43 Years – 72 Years
• Healthy volunteers: Accepted

Summary

R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic fibrosis. R2C2 II study is designed to confirm the hypothesis that RAAS is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

Detailed description

Follow up of abdominal obesity patients from the R2C2 cohort study.

Conditions

• Obesity, Abdominal

Interventions

Type	Name	Description
OTHER	Urine sample	dosages on one spot and 24h collection
OTHER	Blood sample	dosages
OTHER	Assessment of sleep apnea syndrome
OTHER	Electrocardiogram
OTHER	Glucose tolerance test
OTHER	Echocardiography
OTHER	cardiac and abdominal magnetic resonance imaging
OTHER	Ambulatory blood pressure monitoring
OTHER	Echotracking
OTHER	Pulse wave velocity
OTHER	Composition of body mass by Dual x-ray absorptiometry

Timeline

• Start date: 2012-11-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2012-10-30
• Last updated: 2015-08-24

Locations

1 site across 1 country: France