Trials / Unknown

UnknownNCT01716572

Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopy in Patients With Upper Gastrointestinal Bleeding

Erythromycin Versus Gastric Lavage to Improve Quality of Endoscopic Examination in Patients With Upper Gastrointestinal Bleeding. A Prospective Randomized Trial.

Status: Unknown
Phase: Phase 3
Study type: Interventional
Enrollment: 122 (estimated)

Sponsor: Hospital Universitari de Bellvitge · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Not accepted

Summary

Detailed description

The researchers will investigate whether erythromycin infusion is better than gastric lavage prior to emergency endoscopy to improve the quality of examination in patients with upper gastrointestinal bleeding. One hundred and twenty-two patients admitted within 12 hours after hematemesis will be randomly assigned to receive erythromycin infusion or gastric lavage by nasogastric tube prior to emergency endoscopy. The endoscopic procedures will be recorded on Digital Video Disc (DVD). Two endoscopists blinded to the cleansing strategy will assess the quality of examination of the upper gastrointestinal tract by using scales designed by Frossard and Avgerinos . Secondary endpoints will be the need for a second-look endoscopy, the mean number of blood units transfused, the need of surgery or arteriography, and the mean duration of hospitalization

Conditions

Interventions

Type	Name	Description
DRUG	Erythromycin	Intravenous 250 mg of erythromycin, single-dose, 30 minutes before the endoscopy
PROCEDURE	gastric lavage	gastric lavage by nasogastric tube with 1 liter of saline before the endoscopy

Timeline

Start date: 2012-02-01
Primary completion: 2015-09-01
Completion: 2015-12-01
First posted: 2012-10-30
Last updated: 2015-10-08

Locations

1 site across 1 country: Spain

Source: ClinicalTrials.gov record NCT01716572. Inclusion in this directory is not an endorsement.