Clinical Trials Directory

Trials / Terminated

TerminatedNCT01716234

A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)

Phase 1B Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children With Neutropenia (P03579)

Status
Terminated
Phase
Phase 1
Study type
Interventional
Enrollment
142 (actual)
Sponsor
Merck Sharp & Dohme LLC · Industry
Sex
All
Age
3 Months – 17 Years
Healthy volunteers
Not accepted

Summary

The purpose of this dose-escalation study is to evaluate the pharmacokinetics, safety, and tolerability of oral posaconazole in immunocompromised children with neutropenia or expected neutropenia.

Conditions

Interventions

TypeNameDescription
DRUGPosaconazole 12 mg/kg/day BIDPosaconazole oral suspension 12 mg/kg/day divided into 2 doses (BID) (maximum 800 mg/day)
DRUGPosaconazole 18 mg/kg/day BIDPosaconazole oral suspension 18 mg/kg/day divided into 2 doses (BID) (maximum 1200 mg/day)
DRUGPosaconazole 18 mg/kg/day TIDPosaconazole oral suspension 18 mg/kg/day divided into 3 doses (TID) (maximum 1200 mg/day)
DRUGPosaconazole 12 mg/kg/day TIDPosaconazole oral suspension 12 mg/kg/day divided into 3 doses (TID) (maximum 800 mg/day)

Timeline

Start date
2008-04-17
Primary completion
2015-04-01
Completion
2015-04-01
First posted
2012-10-29
Last updated
2018-08-27
Results posted
2016-04-15

Source: ClinicalTrials.gov record NCT01716234. Inclusion in this directory is not an endorsement.