NCT01714479

Skeletal Muscle Response to Amino Acids and Load Carriage Exercise

Skeletal Muscle and Physical Performance Responses to Leucine-Enriched Nutrition Supplementation During Load Carriage

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: United States Army Research Institute of Environmental Medicine · Federal
• Sex: All
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

Warfighters often experience physical overload, as the uniform and associated gear that they carry burdens them with substantial loads. The loads increase energy expenditure to levels that exceed a Warfighter's typical energy intake. The typical assault load is approximately 25 kg, although loads as high as 55 kg are often carried, which when combined with extreme energy expenditures can degrade health and performance, and increase the risk of injury. Branched-chain amino acid (leucine) supplementation may confer protection against the negative effects of operational stress by stimulating muscle protein synthesis and reducing degradation. This study will determine if leucine-enriched nutrition supplementation confers protection against the negative consequences of sustained load carriage exercise, and explore the mechanisms by which leucine might impart protection.

Conditions

• Muscle Loss
• Muscle Anabolism
• Muscle Performance

Interventions

Type	Name	Description
OTHER	Leucine-enriched nutritional supplement	A protein and carbohydrate supplement with high levels of leucine
OTHER	Placebo

Timeline

• Start date: 2012-10-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2012-10-26
• Last updated: 2017-07-21

Locations

1 site across 1 country: United States