NCT01714167

Autologous Bone Marrow Mesenchymal Stem Cell Transplantation for Chronic Stroke

Autologous Bone Marrow Mesenchymal Stem Cell Transplantation for Treatment of Chronic Stroke

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Wenzhou Medical University · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Stroke is one of the leading causes of disability in the world, and stem cell - transplantation provides a promising approach for rehabilitation. The main objective of this study is to evaluate the efficacy of the intracerebral injection of autologous bone marrow mesenchymal stem cells in patients with chronic stroke.

Detailed description

For many stroke survivors, the best hope is a lengthy program of rehabilitation, followed by a life-long process of clinical support. However, even with rehabilitation therapy, 50% to 95% of stroke survivors remain impaired. There is thus a great need for new therapeutic developments for patients with disability after stroke, which is largely unexplored. Regenerative cell-based therapies offer long-term hope for many patients with stroke, as stem cells might be possible for dead or injured neural cells to be replaced after acute stroke. In this study, the investigators will assess the safety and feasibility of intracerebral transplantation of autologous bone marrow mesenchymal stem cells in patients with chronic stroke. The neurological outcome will be determined after transplantation.

Conditions

• Stroke

Interventions

Type	Name	Description
GENETIC	intracerebral stem cell transplantation	Intracerebral transplantation of autologous bone marrow mesenchymal stem cell, 2-4 million stem cells per patient

Timeline

• Start date: 2012-06-01
• Primary completion: 2015-10-01
• Completion: 2015-12-01
• First posted: 2012-10-25
• Last updated: 2015-06-08

Locations

1 site across 1 country: China