NCT01713517

Impact of Insecticide Resistance on Vector Control

Impact of Insecticide Resistance in Anopheles Arabiensis on the Effectiveness of Malaria Vector Control in Sudan

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 28,000 (estimated)
• Sponsor: London School of Hygiene and Tropical Medicine · Academic / Other
• Sex: All
• Age: 6 Months – 10 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to determine whether long lasting insecticidal nets and indoor residual insecticide spraying, alone or in combination, are effective for controlling insecticide resistant anopheles mosquitoes for malaria prevention.

Detailed description

The study will assess the impact that insecticide resistance has on the effectiveness of malaria vector control tools LLIN and IRS. This is done by a cluster randomised trials of universal coverage LLINs versus universal coverage LLINs in combination with IRS, with levels of baseline insecticide resistance in the main vector balanced between the two study arms. In each cluster resistance to the insecticide used on LLINs is monitored, and malaria incidence is estimated from cluster specific cohorts of children followed up over the duration of the study. Resistance impact will be assessed from the ratio of incidence rates in clusters with high compared to those with low resistance and from a continuous measure of resistance expressed as percentage loss of mosquito mortality when exposed to insecticide in standardised WHO tests. Resistance mechanisms will be studied in subsets of study clusters.

Conditions

• Malaria, Falciparum

Interventions

Type	Name	Description
OTHER	Indoor residual insecticide spraying (IRS)	Application of insecticide to interior walls of domiciliary structures to kill malaria vector mosquitoes which rest on walls after taking human blood meal
DEVICE	Long Lasting Insecticidal Nets (LLIN)	Provision of LLIN to all community members in the clusters allocated to the study arm. LLIN protect individuals from bites by malaria vector mosquitoes by providing a physical barrier and insecticidal and repellent effect.

Timeline

• Start date: 2011-04-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2012-10-24
• Last updated: 2012-10-26

Locations

3 sites across 1 country: Sudan