NCT01708642

The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

The Effect of Intraoperative Low Dose Adrenaline on Bleeding in Total Hip Arthroplasty - a Randomized Placebo-controlled Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.

Detailed description

Hip arthroplasty is associated with bleeding, anemia and the need for allogeneic transfusion. Administration of low-dose adrenaline activates the coagulation system and may decrease intraoperative and immediate postoperative bleeding. Thus, the aim of this study is to evaluation whether intraoperative IV-administration of low-dose adrenaline reduces bleeding in elective total hip arthroplasty.

Conditions

• Intraoperative Blood Loss

Interventions

Type	Name	Description
DRUG	Adrenaline	Adrenaline infusion 0.05 microgram / kg / minute
DRUG	Placebo	Intraoperative isotonic saline infusion as placebo for adrenaline.

Timeline

• Start date: 2012-11-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2012-10-17
• Last updated: 2015-02-18

Locations

3 sites across 1 country: Denmark