NCT01707615

Beneficial Effects of Grape Seed Proanthocyanidin Extrat on Progression of Atherosclerotic Plaques in Clinical Use

Beneficial Effects of Grape Seed Proanthocyanidin Extrat on Progression of Carotid Intima-media Thickness and Atherosclerotic Plaques in Clinical Use

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 287 (actual)
• Sponsor: Jie Qiu · Academic / Other
• Sex: All
• Age: 43 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the antiatherogenic effect of GSPE in clinical use

Detailed description

Atherosclerotic plaques indicate the occurrence of ischemia events and how to deal with it is a difficult task for clinical physicians. Grape seed proanthocyanidin extrat (GSPE) has been reported to exert an antiatherogenic effect by inducing regression of atherosclerotic plaques in animal experimental studies. In this study, the antiatherogenic effect of GSPE has been investigated in clinical use.

Conditions

• Atherosclerosis of Arteries of the Extremities, Unspecified

Interventions

Type	Name	Description
DRUG	GSPE	GSPE 240 mg/day (120mg bid)
OTHER	lifestyle intervention	dietary modification making the total ingestion of calories into standard body weight 25 kCal in effect and an individualized home exercise program of a minimum 150 min/week of moderate-intensity physical activity

Timeline

• Start date: 2006-10-01
• Primary completion: 2011-09-01
• Completion: 2011-10-01
• First posted: 2012-10-16
• Last updated: 2012-10-16