NCT01701102

Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery

Optimal Dose of Spinal Mepivacaine Combined With Fentanyl For Knee Arthroscopy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around nerves, blocks nerve conduction, resulting in numbness and weakness) used in the spine, but too low a dose can result in an incomplete block (inadequate anesthesia) in some patients. There is evidence that adding a low dose of fentanyl, a narcotic, to mepivacaine enhances the anesthetic effect. The purpose of this study is to determine the lowest dose of mepivacaine, a local anesthetic, when combined with fentanyl, for which spinal anesthesia is adequate for ambulatory knee arthroscopy.

Conditions

• Arthroscopic Knee Surgery

Interventions

Type	Name	Description
PROCEDURE	Mepivacaine (24 mg) plus fentanyl	Mepivacaine (24 mg) and fentanyl (10 µg)
PROCEDURE	Mepivacaine (27 mg) plus fentanyl	Mepivacaine (27 mg) and fentanyl (10 µg)
PROCEDURE	Mepivacaine (30 mg) plus fentanyl	Mepivacaine (30 mg) and fentanyl (10 µg)
PROCEDURE	Mepivacaine	Mepivacaine 37.5 mg

Timeline

• Start date: 2011-12-01
• Primary completion: 2012-07-01
• Completion: 2013-12-01
• First posted: 2012-10-04
• Last updated: 2016-04-05
• Results posted: 2016-03-10

Locations

1 site across 1 country: United States