NCT01698437

Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Brain Tumors

MR-guided Ultrasound-Neurosurgery for the Treatment of Malignant Brain Tumors

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University Children's Hospital, Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Focused Ultrasound Focused ultrasound is an attractive method for non-invasive thermal ablation of soft tissue tumors. Treatment begins by acquiring a series of MR images of the target organ. The physician then identifies a target volume in the MR images and delineates the treatment contours on the images. Therapy planning software calculates the parameters required to effectively treat the defined target volume. During the treatment an ultrasound transducer generates and focuses ultrasound energy to a focal point, called a sonication. The sonication raises the tissue temperature within a well-defined region to a degree, which causes thermal coagulation. MR images acquired during sonication provide a quantitative, real-time temperature map of the target area to confirm the location of the sonication and the size of the coagulated region. The sonication process is repeated at multiple adjacent points to cover the entire prescribed treatment volume.

Conditions

• Malignant Brain Tumors

Interventions

Type	Name	Description
DEVICE	Non-invasive intervention with focused ultrasound (ExAblate 4000)	Non-invasive brain intervention using MR-guided focused ultrasound

Timeline

• Start date: 2011-02-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2012-10-03
• Last updated: 2016-06-03

Locations

1 site across 1 country: Switzerland