NCT01698346

Pertussis (Tdap) Vaccination in Pregnancy

Impact of Pertussis Vaccination in Pregnancy on Maternal Protection Offered to Young Infants

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 99 (actual)
• Sponsor: Universiteit Antwerpen · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Despite good vaccination coverage, included in national immunization programs in developed countries, the number of reported pertussis cases is rising, also in very young infants. Current immunization strategies fail to protect infants too young to be immunized with the licensed vaccine. Different strategies are possible to close the gap of susceptibility between the loss of maternal antibodies and protection by vaccination. The main aim of the present study is to measure the influence of an adult pertussis booster in pregnant women, on the titer and duration of maternal antibodies in their infants. Early humoral immunity will be assessed and the influence on vaccine response of the infant measured. The present study offers the opportunity to have new insights in neonatal immunological mechanisms against pertussis and a better understanding in strategies to protect infants against pertussis.

Conditions

• Pertussis
• Pregnancy

Interventions

Type	Name	Description
BIOLOGICAL	Pertussis vaccine	Vaccination during pregnancy with a pertussis containing vaccine

Timeline

• Start date: 2012-02-01
• Primary completion: 2015-12-01
• Completion: 2016-12-01
• First posted: 2012-10-03
• Last updated: 2019-10-24

Locations

2 sites across 2 countries: Belgium, Vietnam