NCT01692821

Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process are not fully explored. The development of new instruments for the non-invasive measurement of oxygen tension in retinal vessels now allows for the more precise investigation of these physiological processes. The current study seeks to evaluate the retinal oxygen saturation in healthy subjects while breathing different oxygen mixtures to achieve a hypoxic and a hyperoxic state.

Conditions

• Retinal Oxygenation
• Retinal Blood Flow

Interventions

Type	Name	Description
DRUG	100% oxygen breathing	100% oxygen breathing - 30 minutes
DRUG	15% oxygen in N2 breathing	15% oxygen in N2 breathing - 30 minutes
DRUG	12% oxygen in N2 breathing	12% oxygen in N2 breathing - 30 minutes

Timeline

• Start date: 2012-06-01
• Primary completion: 2012-12-01
• Completion: 2013-01-01
• First posted: 2012-09-25
• Last updated: 2013-01-30

Locations

1 site across 1 country: Austria