NCT01689090

Diameter Changes of Retinal Vessels During Hypoxia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Conditions

• Diabetes Mellitus Type 1
• Diabetic Maculopathy

Interventions

Type	Name	Description
OTHER	COX inhibitor	Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
OTHER	L-NG-monomethyl arginine citrate	Intravenous administration of L-NMMA during recordings of diameter changes of retinal vessels
OTHER	COX inhibitor + L-NG-monomethyl arginine citrate	Combination of interventions. Administration of an eye drop voltaren and 45 minutes later infusion with L-NMMA is started and recording of diameter changes of retinal vessels is performed

Timeline

• Start date: 2012-11-01
• Primary completion: 2016-03-01
• Completion: 2016-03-01
• First posted: 2012-09-20
• Last updated: 2018-10-16

Locations

1 site across 1 country: Denmark