NCT01688284

The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage

The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage.

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (actual)
• Sponsor: Woman's Health University Hospital, Egypt · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to evaluate the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal reproductive profile and in patients with Recurrent Pregnancy Losses (RPL).

Detailed description

Office hysteroscopy examination of the patients at the luteal phase of the natural cycle (day17 to day 20),with endometrial biopsy using pipple curette from the region of the fundus, the biopsy sent to flow cytometry laboratory in South Egypt Cancer Institute to be examined for: 1.1. Phenotypic analysis of uterine natural killer cells: 1.2. Induction and detection of intracellular cytokines by flow Cytometry:

Conditions

• Recurrent Pregnancy Losses

Interventions

Type	Name	Description
DEVICE	office hysteroscopy	Endometrial wash and biopsy is taken at the day around implantation window (day 14\_to day 22)of the menstrual cycle from patients of recurrent miscarriages to evaluate the levels of uterine natural killer cells compared to control of females of normal reproductive outcome

Timeline

• Start date: 2010-03-01
• Primary completion: 2012-08-01
• Completion: 2012-08-01
• First posted: 2012-09-19
• Last updated: 2021-01-07

Locations

1 site across 1 country: Egypt