NCT01687855

Dynamic Alterations of Tongue in Sleep Apnoea Hypopnea Syndrome During Sleep

Observation of the Change in Soft Tissue in OSAH

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 41 (actual)
• Sponsor: Wenzhou Medical University · Academic / Other
• Sex: Male
• Age: 40 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to evaluate the dynamic changes of the tongue in patients with obstructive sleep apnoea hypopnea syndrome (OSAHS) during sleep and while awake by using Ultrafast Magnetic Resonance Imaging (UMRI)

Detailed description

UMRI was undertaken on the upper airway in 21 OSAHS patients and 20 normal people after being deprived of sleep for one night. A series of midline sagittal images of the upper airway were obtained. The dynamic alterations of the tongue size and the distance from the tongue to X axis (an extended line from the anterior nasal spine to posterior nasal spine) and Y axis (a perpendicular line from the center of the pituitary to the X axis) were measured.Statistical comparisons between pairs of means were performed via t-tests using Spss10 software. A probability level of p\<0.05 was considered to be statistically significant.

Conditions

• Obstructive Sleep Apnoea

Interventions

Type	Name	Description
DEVICE	Ultrafast Magnetic Resonance Imaging	MRI was performed with a 1.5 superconducting magnet (Gyroscan Intera type, Philips Co. Holland) in a posterior and anterior neck coil. The sequence used to perform the ultrafast MRI was a fast gradient- echo plus sequence. Technical parameters included: echo time, 12 msec; repetition time, 2.3 msec; flap angle, 250; matrix, 192 × 512; section thickness, 7 mm. The imaging time per slice for this sequence was 0.92 sec. A total of 120 consecutive images were obtained as a single section, with a total imaging time of 110.4 seconds. MRI scanning was carried out with the subject first asleep, then whilst awake after 20 minutes in quiet respiration. All images were inputted to the PACS workstation.

Timeline

• Start date: 2003-02-01
• Primary completion: 2006-05-01
• Completion: 2006-05-01
• First posted: 2012-09-19
• Last updated: 2012-09-19

Locations

1 site across 1 country: China