NCT01687647

Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure

Interest of Morphometric Analysis of Sputum Cytology for Lung Cancer Screening in Workers Highly Exposed to Asbestos - Exploratory Analysis of Biomarkers Predictive for Lung Cancer

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,000 (estimated)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 56 Years
• Healthy volunteers: Not accepted

Summary

Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan. An ancillary study will evaluate the interest of blood predictive biomarkers.

Conditions

• Lung Neoplasms

Interventions

Type	Name	Description
OTHER	low-dose CT-scan AND induced sputum sample AND blood test	All subjects will receive a low-dose CT-scan, a blood test (ancillary study) and provide an induced sputum

Timeline

• Start date: 2012-09-01
• Primary completion: 2015-03-01
• Completion: 2019-12-01
• First posted: 2012-09-19
• Last updated: 2014-04-09

Locations

3 sites across 1 country: France