NCT01686191

Genetic Predictors of Renal Dysfunction Following Heart Transplantation

Pharmacogenomics of Calcineurin Inhibitor Nephrotoxicity in Cardiac Transplantation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus. However, the reason why some people develop kidney problems after a heart transplant, but other people do not, is not fully known. This study plans to learn more about the relationship between a person's genetic make-up (DNA; deoxyribonucleic acid) and the risk of kidney problems after a heart transplant. The long-term goal of this research is to identify genetic variations that may help predict the development of kidney problems after heart transplantation.

Conditions

• Heart Transplantation
• Chronic Renal Insufficiency

Timeline

• Start date: 2012-08-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2012-09-17
• Last updated: 2023-05-10

Locations

1 site across 1 country: United States