NCT01681615

Challenge Test for Acetylsalicylic Acid Hypersensitivity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Helse Stavanger HF · Other Government
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of sensitivity and specificity.

Detailed description

Hypersensitivity to Acetylsalicylic Acid or Aspirin (and other NSAIDS) is a condition that affects up to 2,5% of the population. Most cases are seen in a complex of such hypersensitivity with chronic eosinophilic rhinosinusitis with nasal polyposis and asthma. Despite research in finding a reliable in-vitro-test for the condition, challenge tests are still considered gold standard. So far oral, nasal, inhalation and intravenous routes of administration has been described in literature.

Conditions

• Asthma Aspirin-sensitive
• ASA Intolerant Asthma
• Asthma, Aspirin-Induced
• Asthma, Nasal Polyps, and Aspirin Intolerance

Interventions

Type	Name	Description
DRUG	Acetylsalicylate	1-2 drops
DRUG	Isotonic NaCl	1 drop

Timeline

• Start date: 2012-09-01
• Primary completion: 2013-03-01
• Completion: 2013-12-01
• First posted: 2012-09-10
• Last updated: 2012-09-13

Locations

2 sites across 1 country: Norway