NCT01678495

Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke

Sonothrombolysis Potentiated by Microbubbles as a Novel Treatment of Acute Ischemic Stroke: a Prospective Randomized Pilot Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It has proposed the use of ST without microbubble treatment in randomized association with both intravenous and intra-arterial thrombolysis, but combined treatment (rtPA + U.S.) associated with MB diagnostic not yet been investigated in a randomized study. The aim of this study is to evaluate efficacy of the combined treatment (r-rtPA+US+MB) vs the standard rtPA treatment in a randomized study in consecutive patients with acute ischemic stroke. We expect to demonstrate that the combined treatment (rtPA+US+MB) will be statistically superior to standard treatment in terms of recanalization rate.

Conditions

• Cerebrovascular Stroke

Interventions

Type	Name	Description
OTHER	Sulfur hexafluoride + ultrasounds
DRUG	Recombinant tissue plasminogen activator

Timeline

• Start date: 2012-08-01
• Primary completion: 2015-06-01
• Completion: 2015-07-01
• First posted: 2012-09-05
• Last updated: 2015-08-10

Locations

1 site across 1 country: Spain