NCT01667692

Aizthromycin or Clarithromycin in H-pylori Eradication Regimen

Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Shahid Sadoughi University of Medical Sciences and Health Services · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Detailed description

Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available. HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries. There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs. The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Conditions

• Peptic Ulcer
• Dyspepsia
• H-pylori

Interventions

Type	Name	Description
DRUG	azithromycin	Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics.\[1\] It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.
DRUG	clarithmycin	Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.

Timeline

• Start date: 2011-03-01
• Primary completion: 2011-11-01
• Completion: 2012-03-01
• First posted: 2012-08-17
• Last updated: 2012-08-17

Locations

1 site across 1 country: Iran