NCT01666223

Effect of Bile Acids on GLP-1 Secretion

Effect of Bile Acids in the Gut on GLP-1 Secretion in Healthy Subjects and Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to describe the physiological, pathophysiological and potentially therapeutic implications of bile-induced glucagon-like peptide-1 (GLP-1) secretion in human glucose homeostasis.

Detailed description

The investigators hypothesize that even modest increments in endogenous GLP-1 secretion will elicit important antidiabetic effects of GLP-1. To evaluate whether bile acids have such effects, the investigators plan to perform intraduodenal infusion of two different bile acids and placebo.

Conditions

• Type 2 Diabetes
• Obesity

Interventions

Type	Name	Description
DRUG	Colesevelam	Colesevelam 3750 mg dissolved in 100 ml saline, administered in a feeding tube at time = 0.
DRUG	Chenodeoxycholic Acid	1.250 mg dissolved in 100 ml saline, administered in a feeding tube at time = 0.
OTHER	saline	100 ml saline
DRUG	Colesevelam 3750 mg + chenodeoxycholic acid 1250 mg	Colesevelam and chenodeoxycholic acid dissolved in 100 ml saline, administered in a duodenal tube at time = 0.

Timeline

• Start date: 2012-11-01
• Primary completion: 2013-06-01
• Completion: 2013-06-01
• First posted: 2012-08-16
• Last updated: 2013-12-24

Locations

1 site across 1 country: Denmark