NCT01664611

Daily REmote Ischaemic Conditioning Following Acute Myocardial Infarction

The DREAM Study (Daily Remote Ischaemic Conditioning Following Acute Myocardial Infarction)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: University of Leicester · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Remote ischaemic conditioning (RIC) is known to reduce infarct size post MI when used in the peri/immediate post infarct period. However little is known as to the effect of repeated remote conditioning post-MI (Myocardial Infarction) on not only infarct size, but also on ventricular remodeling and ultimately cardiac failure. In this phase II first in man trial, the investigators intend to carry out daily remote ischaemic conditioning in post MI patients. The principal hypothesis is that RIC applied on a daily basis for 4 weeks following a heart attack improves the ejection fraction at 4 months as assessed by cardiac magnetic resonance imaging.

Conditions

• Post Myocardial Infarction

Interventions

Type	Name	Description
PROCEDURE	Remote Ischaemic Conditioning administered via the inflation of a blood pressure cuff on the upper arm	Suprasystolic blood pressure cuff inflation for set periods to time to render a limb ischaemic followed by periods of deflation to allow for reperfusion.
PROCEDURE	Sham conditioning	Non therapeutic inflation of a blood pressure cuff that does not cause ischaemia/reperfusion injury

Timeline

• Start date: 2012-09-26
• Primary completion: 2016-10-30
• Completion: 2016-10-30
• First posted: 2012-08-14
• Last updated: 2020-01-31

Locations

1 site across 1 country: United Kingdom