NCT01662167

Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy

Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy: a Clinical Trail

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 87 (actual)
• Sponsor: Hormozgan University of Medical Sciences · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of this study was to compare single dose Methotrexate (MTX) to multiple dose MTX.

Conditions

• Pregnancy, Ectopic

Interventions

Type	Name	Description
DRUG	Single	In the single dose regimen, 50 mg/m2 intramuscular methotrexate was given on day one and hCG level was measured on days four and seven. If the hCG level did not decrease by 15% between day four and seven, a second dose of methotrexate was injected on day seven, hCG level was measured weekly until a level of 15 mlU/ml or less was achieved
DRUG	Multipe	In the multiple dose regimen, 1 mg/kg/day intramuscular methotrexate was given on days one, three, five and seven and 0.1 mg/kg/day intramuscular Citrovoram factor was administered on days two, four, six and eight until serum hCG level decreased 15% in 48 hours or four doses of methotrexate was given weekly until serum hCG level of 15 mlU/ml or less was obtained

Timeline

• Start date: 2008-01-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2012-08-10
• Last updated: 2012-08-10

Locations

1 site across 1 country: Iran