NCT01660867

Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 3 Months – 24 Months
• Healthy volunteers: Not accepted

Summary

This is a prospective, randomized, controlled, double-blinded, clinical trial Subject : 3mo \~ 24mo. aged infants with bronchiolitis The effect of 3 % NaCl nebulizer or dexamethasone on admission rate of these infants in ED.

Detailed description

Randomly assigned to one of three groups * Group I : nebulized epinephrine + 0.9% saline + placebo * Group II : nebulized epinephrine + 3% saline + placebo * Group III : nebulized epinephrine + 0.9% saline + dexamethasone Group I received two treatments of nebulized epinephrine mixed 0.9% saline and a total of six oral doses of placebo, group II received nebulized epinephrine mixed 3% saline and oral placebo, and group III received nebulized epinephrine mixed 0.9% saline and oral dexamethasone. The primary outcome is hospital admission within 7 days after the day of enrollment

Conditions

• Acute Bronchiolitis

Interventions

Type	Name	Description
DRUG	3% saline + oral placebo	nebulized epinephrine + 3% saline + placebo =\> nebulized epinephrine + 3% saline
DRUG	0.9% saline + oral dexamethasone	nebulized epinephrine + 0.9% saline + dexamethasone =\> nebulized epinephrine + 0.9% saline

Timeline

• Start date: 2012-08-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2012-08-09
• Last updated: 2018-01-09

Locations

1 site across 1 country: South Korea