NCT01660854

Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites

Re-exposure of Previously Immunized and Challenged Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

In a previous study (NL33904.091.10) the investigators challenged 24 volunteers after Chloroquine Prophylaxis Sporozoites (CPS) immunization with 45, 30 or 15 infected mosquito-bites respectively. The availability of this immunized cohort opens the unique opportunity to determine protection to a heterologous challenge for both of the protected and unprotected volunteers as the previous challenge infection might have served as immunological boost to the unprotected volunteers. In the current observational, proof of principle study, the investigators aim to investigate the protection on an individual basis of these previously immunized and challenged volunteers against a heterologous P. falciparum challenge.

Conditions

• Malaria, Falciparum

Interventions

Type	Name	Description
BIOLOGICAL	Heterologous challenge	challenge by the bites of 5 Plasmodium falciparum infected mosquitoes.
DRUG	Malarone treatment	Three days: 4 tablets 250/100mg per day

Timeline

• Start date: 2012-07-01
• Primary completion: 2013-01-01
• Completion: 2013-01-01
• First posted: 2012-08-09
• Last updated: 2013-02-13

Locations

1 site across 1 country: Netherlands