NCT01660191

A Study Comparing CoQ10 Levels While Taking 3 Different Statins

A Study Comparing the Effects of Pitavastatin, Atorvastatin, and Rosuvastatin on Plasma Levels of CoQ10 (SPARQ)

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 134 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if Pitavastatin lowers CoQ10 less than Atorvastatin or Rosuvastatin.

Detailed description

Statins are known effectively treat high cholesterol and heart disease. However, statins may lower endogenous levels of Coenzyme10 (CoQ10). This decrease in CoQ10 levels may be responsible for side effects such as myalgia. Previous studies have shown that Pitavastatin may not affect CoQ10 levels as other statins do, while still lowering cholesterol. In this study, investigators intend to compare the plasma levels of CoQ10 in patients taking 3 different FDA-approved statins, in equipotent doses.

Conditions

• Hypercholesterolemia

Interventions

Type	Name	Description
DRUG	Pitavastin 4mg
DRUG	Atorvastatin 20mg
DRUG	Rosuvastatin 5mg

Timeline

• Start date: 2011-12-01
• Primary completion: 2013-08-01
• Completion: 2013-10-01
• First posted: 2012-08-08
• Last updated: 2017-01-18
• Results posted: 2017-01-18

Locations

1 site across 1 country: United States