NCT01660009

Adverse Effects of Systemic Hypoglycemia Exposure on Endothelial Function in Humans

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

Prior work suggests exposure to low glucose levels (hypoglycemia) is associated with increased cardiovascular risk. However, whether there is a causal relationship between cardiovascular events and hypoglycemia remains unclear with conflicting data in the literature. In this study, we plan to study whether acute exposure of patients to clinically relevant (50-60 milligrams/deciliter) levels of hypoglycemia induces or worsens blood vessel endothelial dysfunction- a key 1st step in the development of heart attacks and strokes. This will be determined in humans both with and with type 2 diabetes.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
OTHER	Glycemic clamping	During hypoglycemic clamping, individuals will have a blood glucose level of 50-60 mg/dL for approximately 1 hour prior to outcome measurements. During euglycemic clamping, individuals will have a blood glucose level of 85-99 mg/dL for approximately 1 hour prior to outcome measurements.

Timeline

• Start date: 2012-06-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2012-08-08
• Last updated: 2017-08-14

Locations

1 site across 1 country: United States