NCT01658475

P. Gingivalis IgG Titer Test for Periodontitis

Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,387 (actual)
• Sponsor: Okayama University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Accepted

Summary

This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.

Detailed description

Background: Periodontitis is a prevalent silent infectious disease worldwide, and affects lifestyle-related diseases such as diabetes. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Methods: Oral examination was performed and blood IgG antibody titers against periodontal pathogens were measured by ELISA, in 1387 subjects. The cut-off value of IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed.

Conditions

• Periodontitis

Timeline

• Start date: 2007-01-01
• Primary completion: 2009-11-01
• Completion: 2010-03-01
• First posted: 2012-08-07
• Last updated: 2012-08-07

Locations

12 sites across 1 country: Japan