NCT01657136

Ivabradine Versus Beta-blockers in the Treatment of Inappropriate Sinus Tachycardia

Comparison of Ivabradine and Beta-blockers Administration in the Treatment of Inappropriate Sinus Tachycardia

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Policlinico Casilino ASL RMB · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to prospectively compare the effectiveness and safety of ivabradine and beta-blockers in the treatment of inappropriate sinus tachycardia.

Detailed description

Inappropriate sinus tachycardia (IST) is a non-paroxysmal arrhythmia, characterized by a persistently high sinus heart rate (HR) and/or an exaggerated HR response to minimal exertion, and can be responsible for palpitations, asthenia, chest pain, dizziness and syncope, which can be highly invalidating. Conventional treatment of IST, targeted to symptoms control, mainly consists on β-blockers. However, these drugs are often insufficient or not well tolerated because of side effects (mostly hypotension) that usually limit the administered dose. Ivabradine, a sinus rate lowering agent currently employed in Europe in the treatment of stable angina and chronic heart failure, has recently been demonstrated to be effective and safe in the treatment of IST by a few case reports and clinical trials. A randomized clinical trial comparing ivabradine to β-blockers has not be performed yet.

Conditions

• Inappropriate Sinus Tachycardia

Interventions

Type	Name	Description
DRUG	Ivabradine	comparison of different drugs
DRUG	Beta blocker	comparison of different drugs

Timeline

• Start date: 2013-09-01
• Primary completion: 2016-09-01
• Completion: 2016-09-01
• First posted: 2012-08-06
• Last updated: 2016-09-30

Locations

1 site across 1 country: Italy