NCT01655030

Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial to Evaluate the Efficacy of Creatine Monohydrate as Adjunctive Therapy for Bipolar Depression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether creatine monohydrate is effective as an adjuvant treatment for bipolar depression.

Detailed description

Bipolar Depression is associated with high rates of disability and increased mortality. Despite its major negative impact, treatment of Bipolar Depression is still controversial and only partially efficacious, with over half of patients not responding adequately to available treatment. In this context, the use of drugs that modulate energy metabolism has been proposed as promising new option as treatment strategies for bipolar depression. The aim of our proposed study is to perform a 6-week randomized, double-blind, placebo-controlled clinical trial of creatine monohydrate as an adjuvant treatment for bipolar depression.

Conditions

• Bipolar I Disorder
• Current Episode Depressed

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	creatine monohydrate
DIETARY_SUPPLEMENT	placebo

Timeline

• Start date: 2012-07-01
• Primary completion: 2016-03-01
• Completion: 2016-03-01
• First posted: 2012-08-01
• Last updated: 2023-12-05

Locations

1 site across 1 country: Brazil