NCT01654562

The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia

A Repeated Measures Study of Simvastatin on Choroideremia: Simvastatin Intervention and Reversal in Choroideremia Patients and Age-matched Controls.

• Status: Terminated
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: University of Alberta · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Primary objective: To examine the short-term effects of of simvastatin on the vision on males with choroideremia, evaluated by full-field scotopic threshold testing. The investigators hypothesize that they will see a reversible decrease in the dark-adapted vision in participants taking simvastatin.

Conditions

• Choroideremia

Interventions

Type	Name	Description
DRUG	Simvastatin	Simvastatin 40mg daily by mouth for 5 weeks (4-6 week window) followed by 5 week washout period (4-6 week window).

Timeline

• Start date: 2012-12-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2012-07-31
• Last updated: 2014-10-15

Locations

1 site across 1 country: Canada