NCT01648218

Insulin Therapy for Post-transplant Glucocorticoid Induced Hyperglycemia

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 5 (actual)
• Sponsor: Vancouver General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

No consensus guidelines exist for management of post-transplant glucocorticoid induced hyperglycemia, but most published reviews recommend insulin as first line therapy. A variety of insulin regimens have been proposed, including mealtime short-acting regular or analog insulin, once daily neutral protamine hagedorn (NPH) insulin, pre-mixed insulin, or basal insulin alone such as glargine or detemir. However, no randomized trial has ever examined different insulin regimens to determine which most effectively controls post-transplant steroid-induced hyperglycemia. Consequently, the proposed study intends to examine three commonly used insulin regimens used for managing post-transplant once-daily glucocorticoid-induced hyperglycemia to determine which is most effective: * Group 1: Intermediate-acting (NPH) insulin at breakfast * Group 2: Short-acting insulin (regular or aspart) before meals * Group 3: Insulin glargine at breakfast Question/Hypothesis: Among three commonly used insulin regimens, which is most effective for managing post-transplant once-daily glucocorticoid-induced hyperglycemia?

Conditions

• Post-Transplant Glucocorticoid Induced Diabetes

Interventions

Type	Name	Description
DRUG	Neutral protamine hagedorn (NPH) insulin
DRUG	Regular human insulin or Insulin Aspart
DRUG	Insulin glargine

Timeline

• Start date: 2012-08-01
• Primary completion: 2013-04-01
• Completion: 2013-06-01
• First posted: 2012-07-24
• Last updated: 2015-12-09

Locations

1 site across 1 country: Canada