NCT01644370

Children With HIV and Asthma (CHIVAS)

Allergen Specific T Effector and T Regulatory Cell Response to Common Aeroallergens Following Immune Restoration in HIV-infected Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: The HIV Netherlands Australia Thailand Research Collaboration · Academic / Other
• Sex: All
• Age: 2 Years – 18 Years
• Healthy volunteers: Accepted

Summary

To explore allergen-specific effector and regulatory T cell response in HIV-infected children before and after HAART initiation

Detailed description

Recently, US investigators have observed that HIV-infected (HIV+) children on highly active antiretroviral therapy (HAART) have a much greater cumulative incidence of asthma.Regulatory T cells may mitigate the pathogenicity of asthma through the suppression of Th2 responses. Since asthma is predominantly a TH2 mediated condition, we propose that new onset of asthma after HAART in HIV- infected children may be secondary to dysregulated immune reconstitution. The restoration of CD4+ T cell-mediated immunity in HIV+ patients treated with HAART may lead to airway inflammation, narrowing, hyperresponsiveness, and possibly remodeling. The increased incidence of asthma in HIV-infected children treated with HAART is likely secondary to multiple factors that may include hypersensitivity to certain aeroallergens, dysregulation of effector and regulatory T cell response, as well as the imbalance of TH1 vs. TH2 cytokines. Therefore this study will identify the immunopathogenesis of increased airway hyperresponsiveness in HIV-positive patients.

Conditions

• T Cell Response to Asthma in HIV-infected Patients Before and After Starting Treatment

Interventions

Type	Name	Description
DRUG	HAART	as per Thai HIV Treatment guidelines

Timeline

• Start date: 2011-09-01
• Primary completion: 2014-07-01
• Completion: 2015-12-01
• First posted: 2012-07-19
• Last updated: 2016-02-22

Locations

2 sites across 1 country: Thailand