NCT01642745

Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness

Mannitol and Methacholine Responsiveness: Effects of Deep Inhalations

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	Methacholine (Provocholine)	two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL
DRUG	Mannitol (Aridol)	single deep inhalation of dry powder per dose doses range from 0mg - 160mg (cumulative dose range 0mg-635mg).
DRUG	Methacholine (Provocholine)	two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL every 20 seconds a deep inhalation is performed

Timeline

• Start date: 2011-11-01
• Primary completion: 2013-02-01
• Completion: 2013-02-01
• First posted: 2012-07-17
• Last updated: 2016-10-27

Locations

1 site across 1 country: Canada