NCT01641913

Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients

Determination of Intestinal Permeability and Response to Treatment in Patients With Eosinophilic Esophagitis

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Do patient's with eosinophilic esophagitis have increased small intestinal permeability and if this changes in response to topically administered esophageal steroids?

Detailed description

Eosinophilic esophagitis is an allergy mediated disease in which antigens exposed to the gastrointestinal tract trigger a combined immediate hypersensitivity. The investigators anticipate that patients with active eosinophilic esophagitis will have increased intestinal permeability on urine collection of sugars. The investigators are not sure whether these findings will be found in patients who have been successfully treated with topical esophageal steroids. Improvement in intestinal permeability would be perceived as indicating that esophageal disease drives the intestinal permeability. Lack of improvement would indicate that eosinophilic esophagitis is a more systemic disease in which increased small bowel permeability is a marker or perhaps important driver of the disease.

Conditions

• Eosinophilic Esophagitis

Interventions

Type	Name	Description
OTHER	Absorbable sugars	Lactulose (1,000 mg) and mannitol (200 mg). For the liquid formulation, these sugars will be administered in 250 ml of water. After oral ingestion of the sugars in liquid form, urine will be collected every 30 minutes for the first 2 hours.

Timeline

• Start date: 2012-08-01
• Primary completion: 2014-01-01
• Completion: 2014-02-01
• First posted: 2012-07-17
• Last updated: 2014-06-24

Locations

1 site across 1 country: United States