NCT01640145

Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly

Impact of Acute Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly: a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: Male
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge viewed from an individual, and a socioeconomic point of view. Nevertheless, several studies have proved muscle tissue to be markedly affected by physical activity and nutritional interventions even at old age. Recently, a study in young individuals showed that an acute bout of easily tolerated low intensity exercise can prolong the muscle building effects of a milk protein intake compared to a non-exercised situation. Therefore, the major aim of the present project is to evaluate, whether a low intensity exercise regime in conjunction with milk protein supplementation can induce positive adaptations on parameters related to muscle size and function in elderly. The study focuses on the acute muscle protein synthesis response to low intensity exercise and protein supplementation measured with stable isotope tracer techniques. It is hypothesized that light muscle activity can augment and prolong the effects of protein feeding. If a light resistance exercise protocol as investigated in the present project can prove beneficial, elderly, frail elderly, and individuals undergoing rehabilitation can challenge sarcopenia in a new and tolerable way.

Conditions

• Skeletal Muscle Protein Synthesis in Elderly
• Protein Kinetics
• Sarcopenia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Protein	Whey protein intake
OTHER	Exercise	Unilateral low intensity exercise

Timeline

• Start date: 2012-07-01
• Primary completion: 2013-01-01
• Completion: 2014-10-01
• First posted: 2012-07-13
• Last updated: 2015-01-06

Locations

1 site across 1 country: Denmark