NCT01639157

Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine

Human Laboratory Study of the Impact of Buspirone Maintenance on the Reinforcing, Subjective and Performance Effects of Cocaine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: William Stoops · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Cocaine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce cocaine use, however, these interventions are not universally effective and treatment effects diminish over time. Development of a pharmacotherapy that enhances the efficacy of these interventions is a priority for the National Institute on Drug Abuse. This study proposes to determine the impact of buspirone maintenance on self-administration of cocaine and alternative reinforcers. These preliminary data will be used to support further research developing buspirone as a pharmacotherapy for cocaine use disorders. We hypothesize that buspirone will attenuate the reinforcing effects of cocaine and increase the reinforcing effects of alternative reinforcers.

Conditions

• Cocaine Use Disorders

Interventions

Type	Name	Description
DRUG	Buspirone	Subjects will be maintained on oral buspirone (10 mg administered 3 times daily) for 6 days each during the study in random order.
DRUG	Placebo	Subjects will be maintained on oral placebo (0 mg administered 3 times daily) for 6 days each during the study in random order.

Timeline

• Start date: 2012-09-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2012-07-12
• Last updated: 2016-02-19
• Results posted: 2016-02-19

Locations

1 site across 1 country: United States