NCT01633554

ST-2; a Non-invasive Fibrosis Marker for Chronic Hepatitis B

The Ability of Prediction of Fibrosis for ST-2 as a Non-invasive Marker in Chronic Hepatitis B

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 95 (estimated)
• Sponsor: Turkiye Yuksek Ihtisas Education and Research Hospital · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

IL-33 is a recently identified number of the IL-1 family. Hepatic over-expression of IL-33 has been recently linked to liver fibrosis. ST-2 exerts pro-inflammatory effects of IL-33. We aimed to determine ability of ST2 to predict fibrosis in chronic hepatitis B.

Detailed description

ST-2 is an IL-1 receptor family member and exists in both a membrane-bound isoform and a soluble (sST2) isoform. It has a functional ligand (Interleukin-33) and via ST-2/IL-33 inflammation and immunity is regulated. Hepatic over-expression of IL-33 has been recently linked to liver fibrosis. ST-2 exerts pro-inflammatory effects of IL-33. We aimed to determine ability of ST2 to predict fibrosis in chronic hepatitis B.

Conditions

• Sequela of Chronic Liver Disease

Timeline

• Start date: 2011-01-01
• Primary completion: 2012-07-01
• Completion: 2012-09-01
• First posted: 2012-07-04
• Last updated: 2012-07-04

Locations

1 site across 1 country: Turkey (Türkiye)