NCT01631968

Incidence of Infection After Total Knee Arthroplasty Using an Erythromycin and Colistin Loaded Cement or a Standard Cement

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,948 (actual)
• Sponsor: Parc de Salut Mar · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective randomized study in cemented primary total knee arthroplasty. In one group the cement used was standard cement, without any antibiotics and in the other group the cement used was loaded with 0.5 g of erythromycin and 3 million units of colistin in 40 g of cement. In all cases intravenous antibiotics prophylaxis against infection was used. In both groups the cement was mechanically mixed in a vacuum. One deep drain tube was placed for 24 hours in all cases. The main variable was the presence of infection according to the Center of Disease Control criteria with a minimum of 12 months follow-up.

Conditions

• Infection After Primary Total Knee Arthroplasty

Interventions

Type	Name	Description
PROCEDURE	Cement without antibiotic.
PROCEDURE	Cement with erytromycin and colistin.

Timeline

• Start date: 2007-09-01
• Primary completion: 2011-03-01
• Completion: 2012-05-01
• First posted: 2012-06-29
• Last updated: 2016-02-24

Locations

1 site across 1 country: Spain