NCT01631916

Corticosteroids in Community-acquired Pneumonia

Use of Corticosteroids in Children Hospitalized With Community-acquired Pneumonia

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Hospital General de Niños Pedro de Elizalde · Academic / Other
• Sex: All
• Age: 2 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the efficacy of addition of corticosteroid therapy to antibiotics in children hospitalized with community-acquired pneumonia. The hypothesis is that the use of corticosteroids decreases the length of stay in children hospitalized with community-acquired pneumonia.

Detailed description

Community-acquired pneumonia (CAP) is a common problem in pediatric practice. The lower respiratory tract infections, particularly pneumonia, are a frequent cause of morbidity in children and is the leading cause of mortality in developing countries. In the last 20 years, despite several research, only a small decrease in morbidity and mortality has been achieved. Corticosteroids have an immune-modulation effect, not completely elucidated. Most likely, this effect is due to down regulation of pro-inflammatory cytokines. We postulate that adding corticosteroids to antibiotic treatment of CAP might change the immune response and thereby reduce morbidity, leading to a decrease in patients hospital length of stay.

Conditions

• Community-acquired Pneumonia

Interventions

Type	Name	Description
DRUG	corticosteroid	Dexamethasone 0.6 mg/kg/day or Methylprednisone 1 mg/kg/day

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-12-01
• Completion: 2017-03-01
• First posted: 2012-06-29
• Last updated: 2016-02-29

Locations

1 site across 1 country: Argentina