NCT01631006

Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy

Acute Hemodynamic Effects of Continous Positive Airway Pressure (CPAP) in Patients With Hypertrophic Cardiomyopathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease, is a cause of disability including heart failure, atrial fibrillation, and sudden death, with an annual mortality varying from 1% to 6%. Obstructive sleep apnea (OSA) is extremely common among patients with established cardiovascular disease, including hypertension and atrial fibrillation and when present may contribute to worse cardiovascular outcome. Although patients with HCM do not necessarily have typical characteristics of patients with OSA, such as obesity and increasing age, there is recent evidence that OSA is extremely common among patients with HCM, with a prevalence ranging from 32% to 71%. The presence of OSA among patients with HCM is independently associated with worse structural and functional impairment of the heart, including atrial and aorta enlargement, worse New York Heart Association functional class, and worse quality of life. Therefore, the recognition and treatment of OSA is a new area of research that may impact in the management of patients with HCM.

Conditions

• Non-obstructive Hypertrophic Cardiomyopathy
• Obstructive Hypertrophic Cardiomyopathy

Interventions

Type	Name	Description
DEVICE	CPAP	A low or high CPAP pressure is delivered for 20 minutes

Timeline

• Start date: 2012-01-01
• Primary completion: 2012-12-01
• Completion: 2013-04-01
• First posted: 2012-06-28
• Last updated: 2014-12-19

Locations

1 site across 1 country: Brazil