NCT01630187

Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony, During Elective Cesarean Section

Comparison of Two Doses of Carbetocin for Prevention of Uterine Atony During Elective Cesarean Section: a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effectiveness of two doses of carbetocin (50 mcg vs 100 mcg) in preventing uterine atony during elective cesarean section.

Detailed description

Postpartum hemorrhage is a major cause of mortality and morbidity in the world, and it is most often caused by uterine atony. To prevent this complication, uterotonic medication is used during elective cesarean section. Carbetocin, a long-acting synthetic analogue of oxytocin, has been used for this purpose for many years. This medication has numerous side effects: hypotension, tachycardia, nausea, vomiting, chest pain, etc. Using a smaller dose of carbetocin might lower the incidence of these side effects, without compromising prevention of uterine atony in a low-risk group of patient.

Conditions

• Uterine Atony
• Post-partum Hemorrhage

Interventions

Type	Name	Description
DRUG	Carbetocin	Administration of carbetocin 50 mcg , after clamping the umbilical cord
DRUG	Carbetocin	Administration of carbetocin 100 mcg , after clamping the umbilical cord

Timeline

• Start date: 2012-04-01
• Primary completion: 2012-07-01
• Completion: 2012-07-01
• First posted: 2012-06-28
• Last updated: 2013-05-29

Locations

1 site across 1 country: Canada