NCT01626911

Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Nanjing University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished). In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.

Conditions

• Acute Pancreatitis

Interventions

Type	Name	Description
PROCEDURE	Continuous regional arterial infusion of low molecular weight heparin in celiac trunk	Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement.
OTHER	General treatment	Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.

Timeline

• Start date: 2011-09-01
• Primary completion: 2013-12-01
• First posted: 2012-06-25
• Last updated: 2013-12-09

Locations

1 site across 1 country: China