Trials / Completed
CompletedNCT01626183
Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia
Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).
Detailed description
OBJECTIVES: * Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus). * Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow). OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | RNA analysis | |
| GENETIC | proteomic profiling | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2012-05-01
- Primary completion
- 2016-05-01
- Completion
- 2016-05-01
- First posted
- 2012-06-22
- Last updated
- 2016-05-17
Source: ClinicalTrials.gov record NCT01626183. Inclusion in this directory is not an endorsement.